The Wallace Lab

We study how organisms respond to their environment, focusing on molecular mechanisms used by fungi. We collect and analyze genome-scale datasets to understand how fungi dynamically reorganize their RNA and protein to adapt to environmental change. This includes how fungi adapt to infect human hosts.

Disambiguation: This is the (Edward) Wallace Lab studying RNA and Systems Biology in Fungi, not to be confused with the (Stephen) Wallace Lab studying Chemical and Synthetic Biology, also in Edinburgh.

News

Workflows paper accepted

Our paper on choosing and using bioinformatics software is accepted at PLoS Computational Biology!

This was led by Dr. Mike Jackson from EPCC.

Posted 25 Feb 2021 by Edward

Welcoming new lab members for 2021

Welcome to: Louis Headley, a joint PhD student with Ramon Grima; Aphena Huang, Emma Mackenzie, Paddy Harker, and Sophie Winterbourne for their undergraduate honours projects.

Farewell to Jamie Auxillos, who is moving to a new postdoc position in Denmark!

Posted 18 Jan 2021 by Edward

Evolution of the Ssd1 pseudonuclease

Happy New Year! Our paper on evolution of the Ssd1 RNA-binding protein has been accepted!

This paper describes a change in protein function over evolutionary time: we show that ancestors of yeast Ssd1 were RNases related to Dis3L2, and that the nuclease activity has been lost repeatedly during fungal evolution.

Posted 02 Jan 2021 by Edward

Working with the Software Sustainability Institute

New blogpost on research software, with the Software Sustainability Institute, especially the riboviz project.

Posted 09 Dec 2020 by Edward

Posts

Favourite Papers In The Lab

Posted 26 Nov 2020 by Flic

Safe and Productive Science-ing During an Epidemic

Posted 11 Mar 2020 by Edward

Collaborative PhD opportunities for October 2020 entry (Archive)

Posted 26 Nov 2019 by Edward

Scientist and Parent: The Bereaved Parent