Image credit: Tom Humberstone

We study how organisms respond to their environment, focusing on molecular mechanisms used by fungi. We collect and analyze genome-scale datasets to understand how fungi dynamically reorganize their RNA and protein to adapt to environmental change. This includes how fungi adapt to infect human hosts.

Disambiguation: This is the (Edward) Wallace Lab studying RNA and Systems Biology in Fungi, not to be confused with the (Stephen) Wallace Lab studying Chemical and Synthetic Biology, also in Edinburgh.

Posted 25 Feb 2021 by Edward

Welcome to: Louis Headley, a joint PhD student with Ramon Grima; Aphena Huang, Emma Mackenzie, Paddy Harker, and Sophie Winterbourne for their undergraduate honours projects.

Farewell to Jamie Auxillos, who is moving to a new postdoc position in Denmark!

Posted 18 Jan 2021 by Edward

Happy New Year! Our paper on evolution of the Ssd1 RNA-binding protein has been accepted!

This paper describes a change in protein function over evolutionary time: we show that ancestors of yeast Ssd1 were RNases related to Dis3L2, and that the nuclease activity has been lost repeatedly during fungal evolution.

Posted 02 Jan 2021 by Edward
Posted 09 Dec 2020 by Edward